A case-control study on association between OAS1 polymorphism and susceptibility to spontaneous preterm birth and preterm premature rupture of membranes / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 898-902, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-279029
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between the genetic polymorphism of 2',5'-oligoadenylate synthetase 1 (OAS1) and susceptibility to spontaneous preterm birth (SPTB) and preterm premature rupture of membranes (PPROM).</p><p><b>METHODS</b>The case-control study consisted of 599 preterm infants including 171 cases of PPROM, and 673 full-term infants without maternal histories of SPTB and PPROM as controls. The single nucleotide polymorphism (SNP) at OAS1 intron 5, rs10774671, was analyzed by polymerase chain reaction-restriction fragment length polymorphism.</p><p><b>RESULTS</b>No significant differences were observed between the case and control groups in the frequencies of genotypes (AA, GA, and GG) and alleles (A and G) of OAS1 rs10774671. When the case group was divided into two subgroups with or without PPROM, no significant differences in the genotype and allele frequencies were found between each subgroup and the control group. When the case group was divided into three subgroups with different gestational ages at SPTB, no significant differences in the genotype and allele frequencies were detected between each subgroup and the control group.</p><p><b>CONCLUSIONS</b>No association is identified between OAS1 SNP and susceptibility to SPTB and PPROM.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Rupture prématurée des membranes foetales
/
2',5'-Oligoadenylate synthetase
/
Études cas-témoins
/
Prédisposition génétique à une maladie
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Polymorphisme de nucléotide simple
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Naissance prématurée
/
Génétique
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
/
Nouveau-né
langue:
Chinois
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2015
Type:
Article
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