Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--Single factor, and two-factor tests for encapsulation process / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effects of all factors during the process of urea encapsulation of gamma-linolenic acid on the purity and yield.</p><p><b>METHOD</b>To observe the material proportions, time, temperature and purity using single-factor and two-factor tests.</p><p><b>RESULT</b>Single-factor test showed that the optimal ratio of all materials (oil, urea and 95% ethanol) was 138. A 30% purity after single encapsulation process was obtained, at the best temperature range was - 15 degrees C-20 degrees C, for 24 hours. Two-factor test showed that the optimal ratio of oil, urea and ethanol was 138, where the concentration of ethanol was 90%-95%. The purity reached 90% or higher, with three-time encapsulation process.</p><p><b>CONCLUSION</b>An optimized process was identified where material ratios, encapsulation time, temperature, and ethanol concentrations were determined using single-factor and two-factor tests.</p>