Absorption transport mechanism of puerarin oil-in-oil nanoemulsion / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2674-2678, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-279377
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mechanisms of the oil-in-oil nanoemulsions transport through the gastrointestinal tract and the transport efficiency changed with its different particle size in the lymphatic channels.</p><p><b>METHOD</b>The behavior of nanoemulsions in vivo and their absorption via lymph after oral administration was investigated, with the transport efficiency and absorption pathway of nanoemulsions clarified by lymph duct cannulation in rats.</p><p><b>RESULT</b>It suggested about 36.8% of puerarin nanoemulsions was transported into systematic circulation via lymph. Nanoparticles with different size absorbed by the lymphatic channels varied as the degree of transportion.</p><p><b>CONCLUSION</b>The degree of absorption and particle transport is inversely proportional to the size.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Taille de particule
/
Transport biologique
/
Pharmacocinétique
/
Rat Sprague-Dawley
/
Absorption
/
Émulsions
/
Nanoparticules
/
Isoflavones
/
Lymphe
/
Métabolisme
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2010
Type:
Article
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