Study on excretion of stilbene glycoside (THSG) and its beta-cyclodextrin inclusion / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2620-2623, 2010.
Article
de Zh
| WPRIM
| ID: wpr-279387
Bibliothèque responsable:
WPRO
ABSTRACT
The excretion characteristics of stilbene glycoside (THSG) and its beta-cyclodextrin inclusion in bile, urine and feces after oral administration to rats were studied. Bile for 24 h, urine and feces for 72 h were collected. The content of THSG was determined by HPLC-UV. The established HPLC-UV method was available for the analysis of THSG in excreta and corresponded to the requirement of biological sample analysis. After given THSG and its beta-cyclodextrin inclusion, the amount of prototype THSG in feces were 3.27% and 0.61%, meanwhile THSG in bile were 0.20% and 0.18%, respectively. Only a little THSG was found in urine. The result showed that beta-cyclodextrin inclusion reduced the fecal excretion of THSG. However, the characteristic of urinary and biliary excretion wasn't changed.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Physiologie
/
Stilbènes
/
Bile
/
Transport biologique
/
Corps d'inclusion
/
Chimie
/
Administration par voie orale
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Chromatographie en phase liquide à haute performance
/
Rat Sprague-Dawley
/
Sécrétions corporelles
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2010
Type:
Article