Progress and application of phosphoproteomics in the proteomics of liver pathological and physiological state / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1004-1017, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-279451
ABSTRACT
The phosphorylation is one of most common protein post-translational modifications. The protein phosphorylation plays important roles in the life through the reversible process of phosphorylation and dephosphorylation by kinases and phosphatases. Systematical analysis of the phosphorylation state of proteins would greatly help to reveal the mystery of the life. Recently, with the development of mass spectrometer, bioinformatics sortwares and enrichment methods of phosphopeptides, phosphorylation stduy of orgnism proteins by mass spectrometer has become mature gradually. Liver is one of the most important metabolic and immune organs. In-depth study of protein phosphorylation in liver is of great importance to reveal its function. And booming phosphoproteomics has been applied into the study of liver, which has deepened the knowledge of molecular mechnism of its physiology and pathology states. Here, we review the recent progress on the research and development of phosphoproteomics and their application in liver proteomics study.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Phosphopeptides
/
Phosphorylation
/
Physiologie
/
Spectrométrie de masse
/
Maturation post-traductionnelle des protéines
/
Biologie informatique
/
Protéomique
/
Foie
/
Métabolisme
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Biotechnology
Année:
2014
Type:
Article
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