Association between anxiety-depression and 5-HTTLPR gene polymorphism in school-aged twins / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 61-66, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-279896
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between anxiety-depression and 5-HTTLPR gene polymorphism in school-aged twins.</p><p><b>METHODS</b>A total of 147 pairs of twins (47 pairs of monozygotic twins, 100 pairs of dizygotic twins) aged 8-12 years from Baotou and Hohhot were selected as respondents. The Achenbach Child Behavior Checklist (CBCL) was used to calculate the scores of anxiety-depression factors in school-aged twins. The DNA was extracted from oral epithelial cells, and polymerase chain reaction was applied for 5-HTTLPR genotyping. The generalized estimating equation (GEE) was used to analyze the effect of 5-HTTLPR polymorphism and family environment on anxiety-depression in school-aged twins.</p><p><b>RESULTS</b>The children with LS and SS genotypes had significantly higher scores of anxiety-depression factors than those with LL genotype (χ2=3.938, P<0.05). The interaction of 5-HTTLPR genotype with family cohesion and family rearing patterns had a significant impact on the scores of anxiety-depression factors in twins (χ2=6.129 and 7.665, both P<0.05).</p><p><b>CONCLUSIONS</b>5-HTTLPR genotype is significantly correlated with the scores of anxiety-depression factors in school-aged twins. In the family with high cohesion and an autocratic family rearing pattern, S allele may increase the possibility of anxiety-depression in twin children.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anxiété
/
Polymorphisme génétique
/
Jumeaux
/
Dépression
/
Transporteurs de la sérotonine
/
Génétique
/
Génotype
Limites du sujet:
Enfant
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2016
Type:
Article
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