Association between CYP1A1*2A polymorphism and susceptibility to childhood acute lymphoblastic leukemia: a Meta analysis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1112-1118, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-279957
ABSTRACT
<p><b>OBJECTIVE</b>To explore the association between CYP1A1*2A polymorphism and susceptibility to childhood acute lymphoblastic leukemia (ALL) through a Meta analysis.</p><p><b>METHODS</b>Inclusion and exclusion criteria were formulated and English and Chinese databases (PubMed, OVID Database, CBM, CNKI, and Wanfang Data) were searched comprehensively. The studies (from January 1999 to April 2015) related to the association between CYP1A1*2A polymorphism and susceptibility to childhood ALL were collected. STATA 12.0 Software was applied to perform the Meta analysis for the articles included.</p><p><b>RESULTS</b>A total of 12 articles were included for analysis (11 English articles and 1 Chinese article), which involved 3 355 cases in total. The results of the Meta analysis showed a significant association between CYP1A1*2A polymorphism and susceptibility to childhood ALL (allele model OR=1.31, 95% CI 1.07-1.61; dominant model OR=1.33, 95% CI 1.13-1.56; codominant model OR=1.30, 95% CI 1.10-1.54). According to the results of a subgroup analysis based on ethnic origin, an increased risk of childhood ALL was observed in both Asian subgroup (dominant model OR=1.57, 95% CI 1.19-2.08; codominant model OR=1.61, 95% CI 1.20-2.17) and the Caucasian subgroup (allele model OR=1.31, 95% CI 1.04-1.63; dominant model OR=1.22, 95% CI 1.00-1.49).</p><p><b>CONCLUSIONS</b>CYP1A1*2A polymorphism may be associated with the genetic susceptibility to childhood ALL.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Cytochrome P-450 CYP1A1
/
Prédisposition génétique à une maladie
/
Leucémie-lymphome lymphoblastique à précurseurs B et T
/
Génétique
Type d'étude:
Étude pronostique
/
Revues systématiques évaluées
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2015
Type:
Article
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