Genotype of Rotavirus Vaccine Strain LLR in China is G10P15 / 病毒学报
Chinese Journal of Virology
; (6): 170-173, 2015.
Article
Dans Zh
| WPRIM
| ID: wpr-280278
Responsable en Bibliothèque :
WPRO
ABSTRACT
Rotavirus is the leading causal agent of severe acute gastroenteritis in children aged <5 years. A specific pharmacologic agent for the treatment of rotavirus-infected children is lacking. In China, only the Luo Tewei oral vaccine (Lanzhou Institute of Biological Products, Shanghai, China), which is produced from Lanzhou lamb rotavirus vaccine (LLR), is available. Studies have hypothesized that the genotype of LLR is G10P[12], To identify the genotype of LLR by reverse transcription-polymerase chain reaction, we showed that the VP7 and VP4 genotypes of LLR were G10 and P[15], respectively, based on sequencing, alignment and phylogenetic analyses. In conclusion, we identified the genotype of rotavirus strain LLR to be G10P[15].
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Phylogenèse
/
Infections à rotavirus
/
Protéines virales
/
Virologie
/
Données de séquences moléculaires
/
Chimie
/
Chine
/
Classification
/
Similitude de séquences d'acides aminés
/
Rotavirus
Limites du sujet:
Humans
Pays comme sujet:
Asia
langue:
Zh
Texte intégral:
Chinese Journal of Virology
Année:
2015
Type:
Article