Research progress in the structure and function of dengue virus non-structural 1 protein / 病毒学报
Chinese Journal of Virology
;
(6): 683-688, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-280309
ABSTRACT
Dengue virus (DENV) is a re-emerging disease transmitted by the Aedes mosquitoes and has become a major public health problem in southern China. Currently, no antiviral drug or effective vaccine exist to control this disease. The chimeric DENV structural protein vaccine cannot elicit balanced levels of protective immunity to each of the four viral serotypes; therefore, non-structural protein components may be required to construct an effective DENV vaccine. The Dengue virus non-structural 1 (DENV NS1) protein plays a critical role in viral pathogenesis and protective immunity. Therefore, immunity to Dengue 1-4 NS1 subtypes may be crucial for the prevention of severe disease. This review attempts to provide an overview about the structure and function of DENV NS1.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Virologie
/
Chimie
/
Protéines virales non structurales
/
Dengue
/
Virus de la dengue
/
Allergie et immunologie
/
Vaccins contre la dengue
/
Génétique
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Virology
Année:
2014
Type:
Article
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