Identification of the isoform in type II receptor of transforming growth factor-beta in patients with acute leukemia and its clinical significance / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 221-224, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-280697
ABSTRACT
Recent research indicates that TGF-beta and type II receptor (TbetaR-II) play an important role in the pathogenesis of tumor. A high frequency of abnormalities in TbetaR-II has been demonstrated in various cancers. To identify the mutation of TbetaR-II in patients with acute leukemia, the bone marrow samples from 6 patients with acute leukemia and 11 normal individuals as control were detected by long-range RT-PCR. To detect a deletion in sequence of the TbetaR-IIgene, the PCR products were cloned to T vector and then sequenced. The results showed that there was existance of the isoform of TbetaR-II in 2 cases out of 6 patients with acute leukemia. These two patients had more poor prognosis than others. In conclusion, there was the isoform of TbetaR-II in partial patients with acute leukemia, and the isoform may be related with prognosis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Données de séquences moléculaires
/
Séquence nucléotidique
/
Leucémie aigüe myéloïde
/
Transduction du signal
/
Facteur de croissance transformant bêta
/
Classification
/
Protein-Serine-Threonine Kinases
/
Récepteurs TGF-bêta
/
Isoformes de protéines
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2006
Type:
Article
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