Reducing plasma homocysteic acid lowers serum C-reactive protein level in children with Kawasaki disease / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1762-1763, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-281543
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of plasma homocysteic acid (HCA) reduction on serum C-reactive protein (CRP) level in children with Kawasaki disease (KD).</p><p><b>METHODS</b>Seventy-six children with KD were divided into 2 equal groups for treatment with aspirin and IVIG, or with vitamin B6 and folic acid besides in addition to aspirin and IVIG. Serum CRP level was tested before and after the treatments, and plasma HCA level was also measured after the treatments.</p><p><b>RESULTS</b>Serum CRP level was comparable between the two groups before the treatment, but significantly reduced after vitamin B6 and folic acid treatment (7.56-/+2.94 mg/L vs 12.23-/+4.16 mg/L, P<0.05). Additional vitamin B6 and folic acid treatment significantly lowered plasma HCA level (4.56-/+1.14 micromol/L vs 7.79-/+1.79 micromol/L, P<0.05), and correlation analysis demonstrated a positive correlation between plasma HCA and serum CRP levels (r=0.697, P<0.01).</p><p><b>CONCLUSION</b>Lowering plasma HCA can decrease serum CRP in children with KD to enhance the therapeutic effect.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sang
/
Protéine C-réactive
/
Acide acétylsalicylique
/
Immunoglobulines par voie veineuse
/
Vitamine B6
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Acide folique
/
Homocystéine
/
Maladie de Kawasaki
Limites du sujet:
Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Bébé
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2007
Type:
Article
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