Association of interleukin-6 and interleukin-18 gene polymorphism with rheumatoid arthritis in Guangdong Han population / 南方医科大学学报
Journal of Southern Medical University
; (12): 1661-1664, 2007.
Article
Dans Zh
| WPRIM
| ID: wpr-281568
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the single-nucleotide polymorphisms (SNPs) at positions -572 and -174 in the promoter region of interleukin-6 (IL-6) gene and at -607 and -137 in the promoter region of interleukin-18 (IL-18) gene for their association with rheumatoid arthritis (RA) in the Chinese Han population in Guangdong Province.</p><p><b>METHODS</b>SNPs of IL-6 and IL-18 genes were detected in 120 patients with RA and 168 normal subjects using polymerase chain reaction with sequence-specific primers (PCR-SSP).</p><p><b>RESULTS</b>SNPs at -572 and -174 of IL-6 gene and at -607 and -137 of IL-18 gene were detected in this population. There was a significant difference in the genotype and allele frequency at -572 and -174 of IL-6 gene and -607 of IL-18 gene (P<0.001), but not in the distribution of genotype frequencies at -137 of IL-18 gene between the RA patients and healthy subjects (P=0.141). A significant difference was found, however, in the allele frequency at -137 of IL-18 (P=0.024). Logistic regression analysis revealed significant association of age, gender, IL-6 gene -572, -174 and IL-18 gene -137 SNPs with RA (P<0.05).</p><p><b>CONCLUSIONS</b>The polymorphisms of the promoter region of IL-6 gene at positions -572 and -174 is probably associated with RA, and further study is needed to understand the relation of the polymorphisms of IL-18 gene at positions -607C/A and-137G/C with RA.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Polyarthrite rhumatoïde
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Études cas-témoins
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Modèles logistiques
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Chine
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Facteurs âges
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Interleukine-6
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Régions promotrices (génétique)
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Prédisposition génétique à une maladie
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Interleukine-18
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Polymorphisme de nucléotide simple
Type d'étude:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limites du sujet:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Pays comme sujet:
Asia
langue:
Zh
Texte intégral:
Journal of Southern Medical University
Année:
2007
Type:
Article