Cellular ultrastructural changes of bone marrow of patients with hemorrhagic fever with renal syndrome / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 165-167, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-281827
ABSTRACT
<p><b>BACKGROUND</b>To observe cytopathogenic effect of Hantaan virus (HV) on cultured human bone marrow cells.</p><p><b>METHODS</b>Light and transmission electron microscopy and direct immunofluorescent technique were applied to study cellular structure especially ultrastructural changes of bone marrow cells from patients with Hantaan virus infection. Bone marrow cells of one healthy volunteer were also studied as control.</p><p><b>RESULTS</b>The antigen of HV was found in bone marrow cells of 20 of 27 HFRS patients by the aid of direct immunofluorescent technique. It was found that the granulocytes had the highest percentage of HV antigen positive cells (76%), followed by monocytes (65%), lymphocytes (40%), megakaryocytes (20%) and the lowest was found in erythrocytes (3.7%). The injury of cell membrane after infection with HV was significantly more severe than that in the control group under the light and electron microscopy.</p><p><b>CONCLUSION</b>This study demonstrated that HV could attack human bone marrow cells and cause cytopathogenic effect on them.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Virologie
/
Virulence
/
Cellules de la moelle osseuse
/
Microscopie électronique à balayage
/
Orthohantavirus
/
Technique d'immunofluorescence directe
/
Allergie et immunologie
/
Fièvre hémorragique avec syndrome rénal
/
Microscopie de fluorescence
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Experimental and Clinical Virology
Année:
2004
Type:
Article
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