Synthesis and antitumor activity of selenophosphocholine analogues containing tegafur / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1184-1187, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-281963
ABSTRACT
<p><b>AIM</b>To synthesize the selenophosphocholine analogues containing tegafur and test their antitumor activities.</p><p><b>METHODS</b>The cyclic glyceroselenophospholopid conjugate of tegafur was synthesized by the reaction of hexaethylphosphorous triamide with N1-(2-furanidyl)-N3-(hydroxyalkyl)-5-fluyorouracil and 1-O-hexadecyl glycerol as well as selenium in one-pot. Cyclic glyceroselenophospholopid conjugate of tegafur reacted with triethylamine to give title compounds.</p><p><b>RESULTS</b>Six new compounds have been synthesized. Their structures were confirmed by 1H NMR, 13P NMR and elemental analysis. Antitumor activity of the title compounds against PGA1 was tested.</p><p><b>CONCLUSION</b>The reaction of triethylamine with cyclic glyceroselenophospholopid conjugate of tegafur very readily occurred, which was finished within 2 h at room temperature. The opening-ring products of trans isomers showed antimutor activity against human uriaryl bladder cancer cell more effective than that of the tegafur.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Phosphoryl-choline
/
Tumeurs de la vessie urinaire
/
Spectroscopie par résonance magnétique
/
Tégafur
/
Composés organiques du sélénium
/
Lignée cellulaire tumorale
/
Traitement médicamenteux
/
Antinéoplasiques
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2006
Type:
Article
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