Yixintong tablet's protection against experimental myocardial ischemia / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>Various models of experimental myocardial ischemia were set up to ovbserve the Yixinton's protection against ischemia.</p><p><b>METHOD</b>Models of experimentally acute myocardial ischemia were made by ligature or medication (pituitrin or isoprenaline) to check the indices of ECG, hemodynamics, and morphology.</p><p><b>RESULT</b>A dosage of Yixintong tablets 100 mg/kg, 200 mg/kg was given to rats by gavage; the rats had undergone a thirty-minute ligatute of coronary lef anterior descending branch, and used as a model of ischemic reperfusion. The observations showed that Yixintong tablets exerted a recovery effect on heart rate, blood pressure, internal pressure of left ventricule and its peak/trough rate (+/- dp/dtmax), and ST segment (electrocardiogram). The tablet markedly reduced the myocardial infarct size of the coronary-ligatured rats. The tablet benefited the rats with pituitrin(iv)- or isoprenaline(ip)-induced acute myocardial ischemia to reverse any ST deviation and T-wave fall.</p><p><b>CONCLUSION</b>Yixintong has a protective and therapeutic action to the experimental myocardial ischemia.</p>