Application of PA-MSHA vaccine adjuvant therapy and TAC scheme for treatment of breast carcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1204-1207, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-282581
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of Pseudomonas aeruginosa MSHA (PA-MSHA) vaccine combined with TAC scheme in the treatment of breast carcinoma.</p><p><b>METHODS</b>A non-blinded, randomized, controlled trial was conducted between January 2008 and June 2008 among 60 patients with breast carcinoma. The patients were randomized into control group (30 cases) with neoadjuvant chemotherapy and PA-MSHA group (30 cases) with PA-MSHA treatment in addition to neoadjuvant chemotherapy. The therapeutic effect, adverse effects, surgical approaches, postoperative complications and cost-effectiveness in both groups were analyzed before and after the treatment.</p><p><b>RESULTS</b>The response rate in PA-MSHA group were significantly higher than that in the control group at 2, 3, and 4 weeks after neoadjuvant chemotherapy (P<0.05). The Karnofsky scores underwent no significant changes in PA-MSHA group after the chemotherapy, but significantly reduced in the control group (P<0.05). The incidence and severity of the toxic reactions and the rates of subcutaneous fluid, skin flap necrosis and infection in PA-MSHA group were significantly lower than those in the control group. The rate of operation following two neoadjuvant chemotherapy sessions was significantly higher in PA-MSHA group than in the control group. The cost of neoadjuvant chemotherapy for a 1% increment of the response rate was also significantly lower in PA-MSHA than in the control group.</p><p><b>CONCLUSION</b>PA-MSHA vaccine combined with TAC scheme can significantly enhance the therapeutic effect of breast carcinoma, lowers the rate of postoperative complications, and improve the efficacy of chemotherapy.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pseudomonas aeruginosa
/
Thérapeutique
/
Tumeurs du sein
/
Protocoles de polychimiothérapie antinéoplasique
/
Doxorubicine
/
Vaccins anticancéreux
/
Traitement néoadjuvant
/
Cyclophosphamide
/
Taxoïdes
/
Utilisations thérapeutiques
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2009
Type:
Article
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