RHD 1227A allele frequency among Rh negative population and random population / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1234-1237, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-282693
ABSTRACT
To investigate the frequency of RHD 1227A allele in Rh negative population and random population, an AS-PCR (allele specific-polymerase chain reaction) method was employed to detect RHD 1227A allele. RHD gene copy was determined by D zygosity test and RHD exon 9 nucleotide sequence analysis. The results showed that among 143 Rh negative donors, forty-one RHD 1227A allele carriers were detected, and 8 (19.51%) out of which were RhCCdee, 32 (78.05%) were RhCcdee, and 1 (2.44%) was RhCcdEe. Thirty-five Rh negative RHD 1227A carriers had RHD gene deletion, and the remaining carriers were RHD 1227A homozygous. Seven (1.43%) individuals were detected with RHD 1227A allele among 489 random donors. They were all G/A heterozygous at RHD 1227 site. Serological test indicated that they were normal Rh positive phenotype. It is concluded that the frequency of RHD 1227A allele is 16.43% among Rh negative population and 0.72% among the random population.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Système Rhésus
/
Données de séquences moléculaires
/
Séquence nucléotidique
/
Chine
/
Délétion de segment de chromosome
/
Clonage moléculaire
/
Analyse de séquence d'ADN
/
Délétion de gène
/
Asiatiques
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2006
Type:
Article
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