Characteristics of T cell receptors recognizing antiphospholipid syndrome associated antigens / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1156-1159, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-282710
ABSTRACT
To understand the characteristics of T cell receptors recognizing antiphospholipid syndrome associated antigen, the characteristics of T cells were analyzed using T cell receptor beta variable region (TCRbetaV) gene spectrotyping in a case of antiphospholipid syndrome (APS). The results indicated that in the case of APS there were 2 dominant T cell clones. The TCRbetaVs sequences of the 2 T cell clones showed the TCRbetaVs belonged to 8 and 23 gene families respectively. The peptides of third complementarity-determining regions (CDR3) in the TCRbetaVs were CASSLLVAGGPRAYNEQFFGPG and CASSLAGFGQPQHFGDG. Comparing the motifs in CDR3 with another autoimmune disease, the motif YNEQFFGPG in TCRbetaV8 and motif QHFGDG in TCRbetaV23 were identical with that of idiopathic thrombocytopenic purpura and systemic lupus erythematosus reported before. In conclusion, some T cell clones proliferating in these autoimmune diseases may recognize the same antigens.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Autoantigènes
/
Région variable d'immunoglobuline
/
Récepteurs aux antigènes des cellules T
/
Syndrome des anticorps antiphospholipides
/
Réarrangement des gènes de la chaine alpha du récepteur pour l'antigène des cellules T
/
Gènes de la chaine bêta du récepteur des lymphocytes T
/
Allergie et immunologie
/
Génétique
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2006
Type:
Article
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