Sodium transport of alveolar type II cells in oleic acid-induced acute respiratory distress syndrome / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To observe the changes of sodium transport of alveolar type II cells in oleic acid-induced acute respiratory distress syndrome (ARDS).</p><p><b>METHODS</b>After isolation of the AT II cells as ARDS model induced by oleic acid, the whole cell sodium current was recorded in 5 h with patch-clamp in whole-cell mode. The effect of beta2-agonist terbutaline on the current was also examined.</p><p><b>RESULTS</b>The sodium currents recorded from AT II cells in ARDS were smaller than that of the control cells, but the current could be stimulated to increase obviously by terbutaline.</p><p><b>CONCLUSION</b>AT II cells can actively transport sodium ion even under conditions of ARDS, but this capacity can not match that of the control cells. Terbutaline can obviously stimulate the sodium current.</p>