Expression of C-erb B-2 and its relation to angiogenesis in nasopharyngeal carcinoma / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the association of C-erb B-2 expression with angiogenesis in nasopharygeal carcinoma.</p><p><b>METHODS</b>Seventy-seven specimens of nasopharygeal carcinoma were examined immunohistochemically for protein expressions of C-erb B-2 and vascular endothelial growth factor (VEGF), and the microvessel density (MVD) was determined by immunostaining of the endothelial cells for factor VIII-related antigen (F8).</p><p><b>RESULTS</b>Positive C-erb B-2 immunostaining was observed in 36.36% (28/77) of the nasopharygeal carcinoma tissues, which had a VEGF positivity rate of 32.48% (25/77). High positivity rate of C-erg B-2 was associated with high positivity rate of VEGF and high MVD (P<0.05).</p><p><b>CONCLUSION</b>The expression of C-erb B-2 may contribute to angiogenesis in nasopharygeal carcinoma.</p>