Expression of vascular endothelial growth factor and metastin in colorectal carcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1584-1587, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-283078
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of vascular endothelial growth factor (VEGF) and metastin in colorectal carcinoma and their association with the clinicopathological features of the malignancy.</p><p><b>METHODS</b>VEGF and metastin expressions were examined immunohistochemically with SP method in 70 specimens of human colorectal carcinoma tissues and adjacent normal tissues.</p><p><b>RESULTS</b>VEGF protein overexpression was detected in 48.6% (34/70)of the colorectal carcinoma tissues but in none of the adjacent normal tissues (P<0.01), and for metastin, the overexpression rate was 28.6% (20/70) in the colorectal carcinoma tissues and 70.0% (49/70) in the normal tissues (P<0.01). The expression of both VEGF and metastin was related to the histological grades, infiltration depth, TNM stage and lymph node metastasis of the tumor (P<0.01 and P<0.05, respectively).</p><p><b>CONCLUSION</b>Immunohistochemical detection of VEGF and metastin can be of value in assessment of the malignancy and in prognostic evaluation of colorectal carcinoma.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tumeurs colorectales
/
Régulation de l'expression des gènes tumoraux
/
Protéines suppresseurs de tumeurs
/
Facteur de croissance endothéliale vasculaire de type A
/
Kisspeptines
/
Génétique
/
Métastase lymphatique
/
Métabolisme
/
Stadification tumorale
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2007
Type:
Article
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