Galectin-1 expression in human colorectal carcinoma and its clinical significance / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1331-1334, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-283138
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between galectin-1 expression and the biological behaviors of human colorectal carcinoma.</p><p><b>METHODS</b>SP immunohistochemistry was used to detect the expression of galectin-1 in 158 paraffin-embedded specimens including 30 normal mucosa, 25 adenoma, 65 colorectal carcinoma and 38 metastatic tumor specimens. Real-time RT-PCR was used to detect galectin-1 mRNA expression in 32 fresh specimens of colorectal carcinoma and normal mucosa.</p><p><b>RESULTS</b>The positive expression level of galectin-1 was significantly different between normal mucosa, adenoma, colorectal carcinomas and metastatic tumors, with positivity rate of 0, 8%, 66% and 86%, respectively (P<0.05). Galectin-1 expression in moderately or well differentiated colorectal carcinomas was significantly lower than that in poorly differentiated ones (P=0.031), and its expression in invasive carcinomas was significantly higher than that in non-invasive carcinomas (P=0.000). Galectin-1 expression in colorectal carcinomas was significantly related with lymph node metastasis (P=0.004). In poorly differentiated colorectal carcinomas, the expression of galectin-1 mRNA was about 2.27 times that in moderately or well differentiated colorectal carcinomas (P=0.00); galectin-1 mRNA expression in invasive carcinoma was 1.98 times that in non-invasive carcinoma (P=0.002). In tumors with lymph node metastasis, galectin-1 mRNA expression was 1.42 times that in tumors without metastasis (P=0.018).</p><p><b>CONCLUSION</b>Galectin-1 can be involved in the development and progression of colorectal carcinoma, and may relate to the infiltration, differentiation and lymph node metastasis of colorectal carcinoma.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
ARN messager
/
Immunohistochimie
/
Tumeurs colorectales
/
Régulation de l'expression des gènes tumoraux
/
Réaction de polymérisation en chaîne
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Biologie cellulaire
/
Galectine 1
/
Génétique
/
Muqueuse intestinale
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2007
Type:
Article
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