A Preliminary Study on the Expression of C-X-C Chemokine Genes in Colonic Mucosa of Patients with Ulcerative Colitis
Journal of the Korean Society of Coloproctology
;
: 735-742, 1998.
Article
Dans Coréen
| WPRIM
| ID: wpr-28335
ABSTRACT
PURPOSE:
Chemokines are potent regulators of the host inflammatory or immune responses. Mucosal synthesis of chemokines may be important in the pathogenesis of mucosal inflammation in ulcerative colitis (UC). We performed this study to investigate the expression of C-X-C chemokine genes in UC.METHODS:
Mucosal tissues were obtained from six normal controls and six UC patients by endoscopic biopsies. In patients with UC, mucosal tissues were separately obtained from both involved and uninvolved regions. RNA was extracted and mRNA levels of five C-X-C chemokines were determined by quantitative reverse transcription-PCR using internal RNA standards.RESULTS:
Mucosal mRNA levels of all chemokines tested increased in the involved region of UC compared with the uninvolved region of UC or normal controls.CONCLUSION:
Our data suggest that mucosal expression of C-X-C chemokines contributes to the pathogenesis of UC
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ulcère
/
Biopsie
/
ARN
/
ARN messager
/
Rectocolite hémorragique
/
Côlon
/
Chimiokines
/
Chimiokines CXC
/
Inflammation
/
Muqueuse
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Journal of the Korean Society of Coloproctology
Année:
1998
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS