Studies on cyclodextrin inclusion complexes of Dragon's blood and its tablets preparation / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2066-2070, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-283796
ABSTRACT
<p><b>OBJECTIVE</b>To study the cyclodextrin inclusion complexes of Dragon's blood for improving the drug solubility and the preparation.</p><p><b>METHOD</b>The inclusion complexes were prepared with beta-cyclodextrin, HP-beta-cyclodextrin, SBE-beta-cyclodextrin and confirmed by DTA. The activity of the inclusion complex was tested by animal experiments. Inclusion complexes tablets were prepared and the dissolution test was performed.</p><p><b>RESULT</b>The solubility of inclusion complexes was increased to 13. 75-168. 39 times. The activity of the inclusion complex was markedly improved, and dissolution rate was 78.69%.</p><p><b>CONCLUSION</b>The cyclodextrin inclusion complexes of Dragon's blood have a good solubility, dissolution rate and pharmacological activity.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Solubilité
/
Comprimés
/
Médicaments issus de plantes chinoises
/
Extraits de plantes
/
Chimie
/
Cyclodextrines
/
Cyclodextrines bêta
/
Stabilité de médicament
/
2-Hydroxypropyl-beta-cyclodextrin
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2008
Type:
Article
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