Investigation on inhibition of HIV III B virus with extractions of Juglans regia / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2535-2538, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-283844
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of anti-HIV III B virus with extractions from Juglans regia, so as to searching for the new and efficacious leading compound of AIDS therapy.</p><p><b>METHOD</b>Phytochemical and chromatographical techniques were used to isolate compounds from J. regia; MT4 cells and HIV III B virus were used to study the effect of anti-HIV activity in vitro. BIACORE 3000 molecule coupled equipment were used for the target research also.</p><p><b>RESULT</b>Two extractions (B&E) were isolated from J. regia which possess the effect of anti-HIV activity. Targets study found that extraction B could affected on HIV-1 gp-41 fusing protein and extraction E could affected on HIV-1 integrase respectively.</p><p><b>CONCLUSION</b>J. regia is a traditional Chinese medicine with active anti-HIV activity and worth to be studied further.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Médicaments issus de plantes chinoises
/
Extraits de plantes
/
Lignée cellulaire
/
Chimie
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Juglans
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2008
Type:
Article
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