Effect of cucurmosin on chronic myeloid leukemia K562 cell line / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 891-894, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-284014
ABSTRACT
This study was aimed to investigate the antitumor effect of pumpkin protein (cucurmosin, CUS) on subcutaneous transplant tumor in chronic myeloid leukemia K562 cell-NOD/SCID mice and leukemia model. The subcutaneous transplant tumor in K562-NOD/SCID mice and leukemia model were established; using two models, the antitumor activity of CUS in mice was evaluated. The results indicated that the inhibitory rate of 0.5 mg/kg and 1 mg/kg CUS on subcutaneous transplant tumor were 53.45% and 59.43% respectively; survival time of mice received 0.25 mg/kg and 0.5 mg/kg CUS was 39.8 ± 5.5 d and 43.4 ± 6.6 d, antitumor rate was 24.9% and 36% respectively. It is concluded that CUS has significant inhibitory effect on mice with CML cell line K562.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Protéines végétales
/
Leucémie myéloïde chronique BCR-ABL positive
/
Souris SCID
/
Souris de lignée NOD
/
Cellules K562
/
Tests d'activité antitumorale sur modèle de xénogreffe
/
Traitement médicamenteux
Limites du sujet:
Animaux
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2013
Type:
Article
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