Microdeletions in the Y chromosome of patients with idiopathic azoospermia / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 111-115, 2002.
Article
Dans Anglais
| WPRIM
| ID: wpr-284062
ABSTRACT
<p><b>AIM</b>To evaluate the occurrence and prevalence of microdeletions in the gamma chromosome of patients with azoospermia.</p><p><b>METHODS</b>DNA from 29 men with idiopathic azoospermia was screened by polymerase chain reaction (PCR) analysis with a set of gamma chromosome specific sequence-tagged sites (STSs) to determine microdeletions in the gamma chromosome.</p><p><b>RESULTS</b>Deletions in the DAZ (deleted in azoospermia) loci sgamma254 and sgamma255 were found in three patients with idiopathic azoospermia, resulting in an estimated frequency of deletions of 10.7% in idiopathic azoospermia men.</p><p><b>CONCLUSION</b>We conclude that PCR analysis is useful for the diagnosis of microdeletions in the Y chromosome, which is important when deciding the suitability of a patient for assisted reproductive technology such as testicular sperm extracion-intracytoplasmic sperm injection (TESE-ICSI).</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oligospermie
/
Prolactine
/
Testostérone
/
Sang
/
Hormone lutéinisante
/
Séquence nucléotidique
/
Hétérochromatine
/
Réaction de polymérisation en chaîne
/
Sites étiquetés par des séquences
/
Délétion de séquence
Limites du sujet:
Adulte
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Asian Journal of Andrology
Année:
2002
Type:
Article
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