Role of chemokine receptor 2 in renal damage induced by deoxycorticosterone acetate-salt hypertension / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 29-35, 2013.
Article
de Zh
| WPRIM
| ID: wpr-284309
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the role of chemokine receptor 2 (CCR2) in the development of salt-sensitive hypertension-induced renal damage.</p><p><b>METHODS</b>We investigated the renal damage induced by uninephrectomy and deoxycorticosterone acetate (DOCA)-salt in mice treated with or without a selective CCR2 antagonist RS504393 for 4 weeks. Sham mice underwent uninephrectomy without receiving DOCA and saline. Systolic blood pressure, urinary excretion of albumin and 8-isoprostane, creatinine clearance, glomerulosclerosis, renal tubulointerstitial injury, and renal monocyte/macrophage infiltration were measured.</p><p><b>RESULTS</b>DOCA-salt treatment led to increased systolic blood pressure, increased urinary excretion of albumin and 8-isoprostane, decreased creatinine clearance, glomerulosclerosis, renal tubulointerstitial injury, and renal monocyte/macrophage infiltration compared with the sham mice (P<0.05). All of them were prevented by CCR2 inhibition (P<0.05).</p><p><b>CONCLUSION</b>Blockade of CCR2 prevents renal damage induced by DOCA-salt treatment, suggesting that CCR2-mediated monocyte/macrophage infiltration may contribute to salt-sensitive hypertension-induced renal injury.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Chlorure de sodium alimentaire
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Modèles animaux de maladie humaine
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Toxicité
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Récepteurs CCR2
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Hypertension artérielle
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Rein
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Métabolisme
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Souris de lignée C57BL
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2013
Type:
Article