Studies on analgesic effects and sites of oxymatrine-carbenoxolone sodium complex / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 822-824, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-284381
ABSTRACT
<p><b>OBJECTIVE</b>To study the analgesic effects and sites of oxymatrine-carbenoxolone sodium complex (OCSC).</p><p><b>METHOD</b>Adopting formalin test, warm water tail-flick test and intracerebroventricularly (icv) injection to observe the analgesic effects of OCSC in mice.</p><p><b>RESULT</b>Intraperitoneally injecting (ip) OCSC (75, 150 mg x kg(-1)) remarkedly inhibited the pain of mice in the formalin test and prolonged latent phases of tail-shrinking of mice, icy OCSC (1.875, 3.75, 7.5 mg x kg(-1)) significantly prolonged latent phases of tail-shrinking of mice, it had dose-dependent effect with concentration.</p><p><b>CONCLUSION</b>The result indicated that OCSC has obvious analgesic effects and its mechanism may be involved in central nervous system (CNS).</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Douleur
/
Pharmacologie
/
Quinolizines
/
Carbénoxolone
/
Chimie
/
Utilisations thérapeutiques
/
Relation dose-effet des médicaments
/
Traitement médicamenteux
/
Alcaloïdes
/
Analgésiques
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2008
Type:
Article
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