Study on drug release of gastrodin ion-activated nasal in situ gel in vitro / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study on the drug release characteristics and mechanism of gastrodin ion-activated nasal in situ gel in vitro.</p><p><b>METHOD</b>Regularity and mechanism of the drug release of gastrodin nasal in situ gel were studied by using the diffusion cell model and the membrane-less dissolution model, respectively. A novel kinesis diffusion cell model was designed according to the characteristics of release environment of nasal cavity. It was used to investigate the effect of adhesiveness on the release of the in situ gel.</p><p><b>RESULT</b>Drug release of gastrodin nasal in situ gel followed the one order release model. Erosion rate of the gel was low and not linearly correlated with the release rate. Compared with gastrodin solution, the nasal in situ gel could increase release time and release amount.</p><p><b>CONCLUSION</b>Gastrodin in the nasal in situ gel is released mainly by diffusion rather than erosion. Release amount of the in situ gel in nasal cavity may be obviously increased because of its adhesiveness.</p>