Identification of new genetic risk factors for prostate cancer / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 49-55, 2009.
Article
Dans Anglais
| WPRIM
| ID: wpr-284710
ABSTRACT
There is evidence that a substantial part of genetic predisposition to prostate cancer (PCa) may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs de la prostate
/
Kallicréines
/
Dépistage génétique
/
Facteurs de risque
/
Protein-Serine-Threonine Kinases
/
Prédisposition génétique à une maladie
/
Protéines sécrétoires de la prostate
/
Diagnostic
/
Génétique
/
Protéines membranaires
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Guide de pratique
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Asian Journal of Andrology
Année:
2009
Type:
Article
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