The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 544-547, 2006.
Article
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| ID: wpr-285081
Responsable en Bibliothèque :
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ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of polymorphisms of CDT1 and GMNN gene, two important genes participating in DNA replication, with the risk of sporadic breast cancer.</p><p><b>METHODS</b>Using polymerase chain reaction-restriction fragment length polymorphism (PCR - RFLP) and the primer-introduced restriction analysis (PIRA)-PCR assay to genotype the CDT1 838G/A and GMNN 387C/A polymorphisms in a case-control study of 427 breast cancer cases and 477 cancer-free controls in a Chinese population.</p><p><b>RESULTS</b>No significant association of the CDT1 838G/A and GMNN 387C/A polymorphisms with the risk of breast cancer was found (adjusted OR:1.16, 95% CI:0.88-1.54 for CDT1 GA+AA genotypes and adjusted OR:0.90, 95% CI:0.67-1.21 for GMNN CA+AA genotypes). However, in the stratified analyses, a significant association of CDT1 GA+AA genotypes with breast cancer risk among subjects with family history of cancer was found (adjusted OR:2.21, 95% CI:1.20-4.09).</p><p><b>CONCLUSION</b>These findings suggest that the CDT1 838G/A and GMNN 387C/A polymorphisms may not play a major role in the etiology of breast cancer, but CDT1 variant may have a potential role only in genetically susceptible women.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Polymorphisme génétique
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Polymorphisme de restriction
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Tumeurs du sein
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Études cas-témoins
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Chine
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Réaction de polymérisation en chaîne
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Protéines du cycle cellulaire
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Prédisposition génétique à une maladie
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Asiatiques
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Ethnologie
Type d'étude:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limites du sujet:
Adult
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Female
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Humans
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2006
Type:
Article