Chemical constituents from Excoecaria acerifclia and their bioactivites / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1145-1147, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-285385
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents of Excoecaria acerifclia and their antitumor activities.</p><p><b>METHOD</b>The constituents were isolated and purified by column chromatography. Their structures were identified by their physicochemical properties and spectral features. Cytotoxicities of the purified compounds were evaluated by MTI method against human cancer cell lines HepG2.</p><p><b>RESULT</b>Eight compounds were isolated and identified as 7-hydroxy-6-methoxy-coumarin (1), 8-hydroxy-6,7-methoxy-coumarin (2), kaempferol (3), kaempferol-3-O-beta-D-glucoside (4), quercetin-3-O-beta-D galactoside (5), kaempferol-3-O-beta-D-glucoside-2"-gallate (6), beta-sitosterol (7), daucosterol (8).</p><p><b>CONCLUSION</b>All compounds were isolated from this plant for the first time. Compounds 5 showed inhibitory activity towards HepG2 with IC50 values of 7.13 mol x L(-1).</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Extraits de plantes
/
Chimie
/
Euphorbiaceae
/
Prolifération cellulaire
/
Cellules HepG2
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2010
Type:
Article
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