Efficacy and safety of topical PUVA treatment for refractory lesions of mycosis fungoides / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 859-862, 2015.
Article
de Zh
| WPRIM
| ID: wpr-286708
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of topical PUVA treatment of refractory lesions of mycosis fungoides.</p><p><b>METHODS</b>From January 2008 to 2014, a total of 10 patients (4 males and 6 females) with mycosis fungoides were treated with topical PUVA in Peking Union Medical College Hospital, including 7 cases in plaque stage and 3 cases in tumor stage. The average number of lesions were 1.9±0.9. The median age of these patients was (46.0±9.4) years. The average course of disease was (12.4±7.7) years. Psoralen was applied topically on treatment area 30 min before total body UVA irradiation treatment, 3 times a week. And the efficiency and safety of the therapy were evaluated.</p><p><b>RESULTS</b>All the patients were treated with topical PUVA with a median total dose of (161.60±135.96) J/cm2 in an average of (18.10±14.61) fractions. Total dose of UVA was (1 953.25±829.73) J/cm2, and total number of treatment was (261.90±116.79) fractions. The total treatment time was (45.80±26.64) months. Complete clinical response (CR) rate was 60.0%, partial response (PR) rate was 30.0%, and the overall response rate (CR+PR) was 90.0%. One patient showed no response. No severe acute or chronic side effects were observed.</p><p><b>CONCLUSION</b>Topical PUVA therapy is effective in the treatment of refractory lesions of mycosis fungoides with little severe side effects.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
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Puvathérapie
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Mycosis fongoïde
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Résultat thérapeutique
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Photosensibilisants
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Utilisations thérapeutiques
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Traitement médicamenteux
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Psoralène
Limites du sujet:
Adult
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Oncology
Année:
2015
Type:
Article