Correlation between chromosome 13q14 deletion and 1q abnormality in multiple myeloma / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 102-105, 2009.
Article
de Zh
| WPRIM
| ID: wpr-287443
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between chromosome 13q14 deletion [del(13q14)] and chromosome 1q abnormality in multiple myeloma (MM).</p><p><b>METHODS</b>The bone marrow plasma cells of 48 previously untreated MM patients were purified by CD138 and magnetic cell sorting system, and interphase fluorescence in situ hybridization (I-FISH) was applied to detect the del(13q14) with D13S319 probe and the abnormalities of chromosome 1q with CEP1 SpectrumOrange probe in sorted MM cells.</p><p><b>RESULTS</b>Among the 48 MM patients, del(13q14) was observed in 22(45.8%) cases, the abnormalities of chromosome 1q were observed in 23 (47.9%) cases, among which 2 were 1q deletion and 21 were 1q duplication. The chromosome 1q abnormality was detected in 16 of the 22 cases of MM with del(13q14) and in 7 of the 26 cases of MM without del(13q14), and there was significant difference between the two groups (chi-square was 10.02, P was less than 0.01).</p><p><b>CONCLUSION</b>There is high frequency of chromosome 13q14 deletion and 1q abnormality in multiple myeloma. The chromosome 1q abnormalities are highly associated with 13q14 deletion.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Chromosomes humains de la paire 1
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Chromosomes humains de la paire 13
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Délétion de segment de chromosome
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Hybridation fluorescente in situ
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Génétique
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Myélome multiple
Limites du sujet:
Aged
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Aged80
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2009
Type:
Article