Terpenoids and sterols from Ricinus communis and their activities against diabetes / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 448-452, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-287567
ABSTRACT
Seven terpenoids and three sterols were isolated from the methanol extracts of the aerial parts of Ricinus communis by chromatography methods and their structures were identified by spectra analysis as ficusic acid( 1), phytol(2), callyspinol(3) , lupeol(4), 30-norlupan-3beta-ol-20-one(5) , lup-20(29)-en-3beta,15alpha-diol(6) , acetylaleuritolic acid( 7), stigmast4-en-3-one(8) , stig-mast-4-en-6beta-ol-3-one(9) , and stigmast4-en-3,6-dione(10). Compounds 1-3 and 5-10 were obtained from this species for the first time and 5 and 6 showed significant inhibitive activity and good selectivity against 11beta-HSD of mouse and human in vitro. [Key words] Ricinus communis; terpenoids; sterols; 11beta-HSD
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Ricinus
/
Stérols
/
Terpènes
/
Chimie
/
Concentration inhibitrice 50
/
11-beta-Hydroxysteroid dehydrogenase type 1
/
11-beta-Hydroxysteroid dehydrogenase type 2
/
Utilisations thérapeutiques
/
Diabète
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2014
Type:
Article
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