Suspected pathogenic mutation identified in two cases with oculocutaneous albinism / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 509-511, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-288042
ABSTRACT
<p><b>OBJECTIVE</b>To detect potential mutations in genes related with non-syndromic oculocutaneous albinism I-IV and ocular albinism type I in two couples who had given births to children with albinism.</p><p><b>METHODS</b>All exons of the non-syndromic albinism related genes TYR, OCA2, TYRP-1, MITF, SLC45A2 and GPR143 were subjected to deep sequencing. The results were verified with Sanger sequencing.</p><p><b>RESULTS</b>For the two female carriers, the coding region of the TYR gene was found to harbor a frameshift mutation c.925_926insC, which was also suspected to have been pathogenic. In one of the male partners, a nonsense mutations c.832C>T was found, which was also known to be pathogenic. Another male partner was found to harbor a TYR gene mutation c.346C>T, which was also known to be a pathogenic nonsense mutation.</p><p><b>CONCLUSION</b>The coding region of the TYR gene c.925_926insC (p.Thr309ThrfsX9) probably underlies the OCA1 disease phenotype.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oxidoreductases
/
Pedigree
/
Glycoprotéines membranaires
/
Données de séquences moléculaires
/
Séquence nucléotidique
/
Chine
/
Exons
/
Albinisme oculocutané
/
Mutation avec décalage du cadre de lecture
/
Mutation faux-sens
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Asie
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2015
Type:
Article
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