Red blood cell on lymphocyte proliferation in rats with chronic unpredictable mild stress / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 423-426, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-288407
ABSTRACT
<p><b>OBJECTIVE</b>To study the changes of rat red blood cells on T, B lymphocytes proliferation in chronic unpredictable mild stress (CUMS).</p><p><b>METHODS</b>Thirty Wistar rats were averagely divided into control group and the CUMS group. The relevant behavioral performance and red blood cells on lymphocytes proliferation Changes by MTT colorimetric were observed.</p><p><b>RESULTS</b>After fourteen days, the growth of weight and organic coefficient of brain decreased in model group (P < 0.05), with a significantly reduced consumption and preference of sucrose solutions, and increased pure water consumption as compared with control group (P < 0.05). Plasma corticosterone levels peaked at seven days but on a declining trend after fourteen days. The rate of red blood cells on T, B lymphocyte proliferation in depression group was lower than non-stress in 7, 14, 21 days (P < 0.05).</p><p><b>CONCLUSION</b>The repeated chronic mild stress stimulation can induce long-time changes in acts and activities and decrease the rate of red blood cells on T, B lymphocytes proliferation, which can provide a new experimental method to observe the red blood cell immune function under the stress.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Stress psychologique
/
Sang
/
Activation des lymphocytes
/
Lymphocytes
/
Rat Wistar
/
Biologie cellulaire
/
Dépression
/
Prolifération cellulaire
/
Modèles animaux de maladie humaine
/
Érythrocytes
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Année:
2010
Type:
Article
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