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PD-1/PD-L1 expressions in liver tissues of patients with chronic HBV infection / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 345-348, 2011.
Article Dans Chinois | WPRIM | ID: wpr-290597
ABSTRACT
<p><b>OBJECTIVE</b>To detect and compare the PD-1/PD-L1 (programmed death 1/programmed death 1 ligand) expressions in the liver tissues of chronic HBV infection patients in immune tolerant phase and those in immune clearance phase.</p><p><b>METHODS</b>Liver biopsy samples were divided into two groups 25 samples from patients in immune clearance phase and 19 samples from patients in immune tolerant phase. PD-1/PD-L1 expressions on T lymphocytes in these liver biopsy specimens were detected by immunohistochemistry method. Percentage of PD-1/PD-L1 positive cells among CD3 positive cells was calculated by semi-quantitative evaluation. Differences between the two groups were statistically analyzed.</p><p><b>RESULTS</b>PD-1/PD-L1 expressions were significantly higher in the patients in immune tolerant phase as compared to that in immune active phase (P < 0.05). No statistical difference found between the two groups for PD-L1 expression in Kupffer cells (P > 0.05).</p><p><b>CONCLUSION</b>PD-1/PD-L1 expression level can reflect the immune functions of chronic hepatitis B patients.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Immunohistochimie / Antigènes CD / Lymphocytes T CD8/ / Hépatite B chronique / Antigène CD274 / Récepteur-1 de mort cellulaire programmée / Foie / Métabolisme Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Hepatology Année: 2011 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Immunohistochimie / Antigènes CD / Lymphocytes T CD8/ / Hépatite B chronique / Antigène CD274 / Récepteur-1 de mort cellulaire programmée / Foie / Métabolisme Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Hepatology Année: 2011 Type: Article