PD-1/PD-L1 expressions in liver tissues of patients with chronic HBV infection / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 345-348, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-290597
ABSTRACT
<p><b>OBJECTIVE</b>To detect and compare the PD-1/PD-L1 (programmed death 1/programmed death 1 ligand) expressions in the liver tissues of chronic HBV infection patients in immune tolerant phase and those in immune clearance phase.</p><p><b>METHODS</b>Liver biopsy samples were divided into two groups 25 samples from patients in immune clearance phase and 19 samples from patients in immune tolerant phase. PD-1/PD-L1 expressions on T lymphocytes in these liver biopsy specimens were detected by immunohistochemistry method. Percentage of PD-1/PD-L1 positive cells among CD3 positive cells was calculated by semi-quantitative evaluation. Differences between the two groups were statistically analyzed.</p><p><b>RESULTS</b>PD-1/PD-L1 expressions were significantly higher in the patients in immune tolerant phase as compared to that in immune active phase (P < 0.05). No statistical difference found between the two groups for PD-L1 expression in Kupffer cells (P > 0.05).</p><p><b>CONCLUSION</b>PD-1/PD-L1 expression level can reflect the immune functions of chronic hepatitis B patients.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Immunohistochimie
/
Antigènes CD
/
Lymphocytes T CD8/
/
Hépatite B chronique
/
Antigène CD274
/
Récepteur-1 de mort cellulaire programmée
/
Foie
/
Métabolisme
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Hepatology
Année:
2011
Type:
Article
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