Detection of TCR-gamma chain gene rearrangement in malignant histiocytosis / 中华血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the lineage of the malignant cells in malignant histiocytosis.</p><p><b>METHODS</b>Polymerase chain reaction with two groups of common primers for TCR-gamma gene was used to analyze the malignant cells of 28 autopsied cases of malignant histiocytosis.</p><p><b>RESULTS</b>Monoclonal TCR-gamma gene rearrangements were detected in 12 out of the 28 samples (43%).</p><p><b>CONCLUSION</b>Most cases diagnosed as malignant histiocytosis in Southwest China seems to be peripheral T-cell lymphomas.</p>