Association of cytochrome P450 2A6 gene polymorphisms with smoking behaviors:a Meta-analysis / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 172-177, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-291657
ABSTRACT
<p><b>OBJECTIVE</b>A Meta-analysis was performed to assess the association of defective hepatic cytochrome P450 2A6 (CYP2A6) gene with smoking behaviors.</p><p><b>METHODS</b>All eligible studies published up to 2014 were searched out from PubMed, China National Knowledge Internet (CNKI), ISI Web of knowledge (ISI), vip citation databases (VIP), Chinese BioMedical Literature (CBM) and Elsevier Science Direct, searching words were "smok*","nicotine dependence","CYP2A6","cytochrome P450 2A6","polymorphism","mut*"and"varia*", while 436 articles were concluded. Meta-analysis was performed using Statal 3.1.</p><p><b>RESULTS</b>A total of ten studies were finally included. We didn't find a significant effect of defective CYP2A6 gene on smoking initiation (fixed effect model (FEM) OR = 0.90, 95%CI 0.78-1.03, I(2) = 25.8%), smoking persistence (random effect model (REM) OR = 0.85, 95%CI 0.59-1.23, I(2) = 66.3%) and smoking cessation (REM OR = 0.89, 95%CI 0.57-1.40, I(2) = 67.1%). But it showed a significant protective effect of CYP2A6*4 on smoking initiation (FEM OR = 0.78, 95%CI 0.61-0.99, I(2) = 28.2%), smoking persistence (FEM OR = 0.53, 95%CI 0.36-0.77, I(2) = 41.0%) and smoking cessation (REM OR = 0.49, 95%CI 0.31-0.80, I(2) = 0.0%).</p><p><b>CONCLUSIONS</b>This Meta-analysis suggested that there was not a protective effect of defective CYP2A6 gene against smoking behaviors. But smokers with whole CYP2A6 gene deletion would be less likely to start smoking, less smoking persistence and more likely to quit smoking successful than smokers with wild CYP2A6 gene.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Trouble lié au tabagisme
/
Aryl hydrocarbon hydroxylases
/
Fumer
/
Chine
/
Arrêter de fumer
/
Délétion de gène
/
Asiatiques
/
Cytochrome P-450 CYP2A6
/
Facteurs de protection
Type d'étude:
Étude pronostique
/
Revues systématiques évaluées
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Chinois
Texte intégral:
Chinese Journal of Preventive Medicine
Année:
2015
Type:
Article
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