Progress in application of targeting viral vector regulated by microRNA in gene therapy: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 707-714, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-292217
ABSTRACT
A safe and effective targeting viral vector is the key factor for successful clinical gene therapy. microRNA, a class of small, single-stranded endogenous RNAs, act as post-transcriptional regulators of gene expression. The discovery of these kind regulatory elements provides a new approach to regulate gene expression more accurately. In this review, we elucidated the principle of microRNA in regulation of targeting viral vector. The applications of microRNA in the fields of elimination contamination from replication competent virus, reduction of transgene-specific immunity, promotion of cancer-targeted gene therapy and development of live attenuated vaccines were also discussed.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Virus
/
Thérapie génétique
/
Régulation de l'expression des gènes
/
MicroARN
/
Vecteurs génétiques
/
Génétique
/
Métabolisme
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Biotechnology
Année:
2010
Type:
Article
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