Prognostic significance of NADPH quinine oxidoreductase 1 overexpression in head and neck squamous cell carcinoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 463-467, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-292262
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the significance of NADPH quinine oxidoreductase 1 (NQO1) protein overexpression on prognostic evaluation of head and neck squamous cell carcinoma (HNSCC).</p><p><b>METHODS</b>NQO1 protein was detected in 162 of HNSCC, 45 cases of adjacent nontumor tissues and 26 samples of normal head and neck epithelia using EnVision immunohistochemical. Correlation between NQO1 overexpression and patients prognosis was also analyzed.</p><p><b>RESULTS</b>The positive rate and strongly positive rate of NQO1 protein were 84.0% (136/162) and 69.8% (113/162) in HNSCC, respectively, and both of which were significantly higher than either those in adjacent nontumor tissues and normal head and neck epithelia (both P < 0.01). NQO1 expression was significantly correlated with the clinical stage, pT and chemoradiotherapy of HNSCC (P < 0.01). Kaplan-Meier survival analysis showed that overall survival and disease-free survival rates were significantly higher in HNSCC patients with high level NQO1 expression than that those with low level of NQO1 expression (Log-rank = 6.625 , P = 0.010;Log-rank = 6.234 , P = 0.013). Additional analysis by Cox proportional hazard regression model showed that high level of NQO1 expression was an independent hazard predictor for overall survival of patients with HNSCC (Wald = 6.626, P = 0.008).</p><p><b>CONCLUSIONS</b>NQO1 expression level is closely correlated with the progression and prognosis of patients with HNSCC. High level of NQO1 expression may be used as an important indicator for patients with poor prognostic HNSCC.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pronostic
/
Région mammaire
/
Carcinome épidermoïde
/
Modèles des risques proportionnels
/
Mortalité
/
NADPH dehydrogenase (quinone)
/
Survie sans rechute
/
Estimation de Kaplan-Meier
/
Tumeurs de la tête et du cou
Type d'étude:
Étude pronostique
Limites du sujet:
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Pathology
Année:
2014
Type:
Article
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