Human foreskin acellular matrix graft: a good scaffold for urethral tissue engineering / 中华男科学杂志
National Journal of Andrology
;
(12): 409-412, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-292362
ABSTRACT
<p><b>OBJECTIVE</b>To provide evidence of using the human foreskin acellular matrix graft for urethral tissue engineering. METH-ODS The human foreskin acellular matrix graft was prepared, its safety and biocompatibility as urethral material were determined by histological observation, cytotoxicity test using primary epithelial cells and experiment in vivo.</p><p><b>RESULTS</b>Intact cells were absent from the foreskin acellular matrix graft. The cytotoxicity test showed that the relative growth rate of the cells was between 75% and 99%, and the cytotoxicity of the foreskin acellular matrix graft was grade 1, consistent with the national standard. With the lengthening of time, the foreskin acellular matrix graft became perfectly compatible with the urothelial cells and the urethral multi-layer structure was restored to normal gradually.</p><p><b>CONCLUSION</b>The human foreskin acellular matrix graft, with its low antigenicity and good biocompatibility, could be a good scaffold for urethral tissue engineering.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Chirurgie générale
/
Transplantation
/
Urètre
/
Cellules cultivées
/
/
Biologie cellulaire
/
Ingénierie tissulaire
/
Techniques de culture de tissus
/
Prépuce
/
Méthodes
Limites du sujet:
Humains
/
Mâle
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2009
Type:
Article
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