Stra8: a specifically expressed gene in premeiotic germ cells' transition from mitosis to meiosis / 中华男科学杂志
National Journal of Andrology
;
(12): 51-55, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-292423
ABSTRACT
Stra8 (stimulated by retinoic acid gene 8) is a specific expression gene in mammalian germ cells' transition from mitosis to meiosis. Stra8 expresses in an anterior to posterior wave from embryonic days 12.5 to 16.5 in germ cells of XX gonads in mice. Meiosis germ cells are observed 1 day after Stra8 expression, which begins in the testis after birth and triggers meiosis entry. Germ cell sex determination is directed by a difference in the timing of entry into meiosis in embryonic gonads. The position of retinoic acid production and CYP26b1 expression that metabolizes RA to an inactive form regulates Stra8 expression. Although cytoplasmic protein Stra8 is necessary for the entry of germ cells into meiotic prophase, the function of the protein remains unknown.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Spermatogenèse
/
Trétinoïne
/
Protéines
/
Expression des gènes
/
Cytochrome P-450 enzyme system
/
Biologie cellulaire
/
Protéines adaptatrices de la transduction du signal
/
Retinoic acid 4-hydroxylase
/
Génétique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2009
Type:
Article
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