Instructional significance of HBV-DNA load in maternal milk on breastfeeding of postpartum women infected with HBV / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 1004-1006, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-292548
ABSTRACT
<p><b>OBJECTIVE</b>To study the instructional significance of HBV-DNA load in maternal milk on breastfeeding of postpartum women infected with HBV.</p><p><b>METHODS</b>HBV-DNA levels in serum and breast milk were detected by FQ-PCR in 152 postpartum women infected with HBV, and HBV-DNA ≥ 1.0 × 10(3) U/ml was defined as HBV positive. Correlation analysis was also conducted to estimate if there were relations in HBV levels in serum and breast milk.</p><p><b>RESULTS</b>HBV-DNA positive rate were 50.66% (77/152) and 36.18% (55/152) in serum and breast milk, respectively. When HBeAg was positive, HBV-DNA positive rate were 95.38% (62/65) and 76.92% (50/65) in serum and breast milk; however when HBeAg was negative, HBV-DNA positive rate were 17.24% (15/87) and 5.75% (5/87) in serum and breast milk. When the concentration of HBV-DNA was 3-4 lg U/ml in serum, HBV-DNA positive rate was 20.00% (5/25) in breast milk; However, when the concentration of HBV-DNA was higher than 5 lg U/ml in serum, HBV-DNA positive rate was 96.15% (50/52) in breast milk.</p><p><b>CONCLUSION</b>The HBV-DNA level in breast milk in postpartum women infected with HBV increased with the HBV-DNA levels in serum. Breastfeeding should be avoided when the concentration of HBV-DNA is higher than 1.0 × 10(3) U/ml in milk.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Virologie
/
Sang
/
Allaitement naturel
/
ADN viral
/
Virus de l'hépatite B
/
Transmission verticale de maladie infectieuse
/
Charge virale
/
Hépatite B
/
Antigènes e du virus de l'hépatite virale B
/
Lait humain
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Preventive Medicine
Année:
2011
Type:
Article
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