Expression of epidermal fatty acid-binding protein and fatty acid synthase in infiltrating ductal breast carcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 381-384, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-293372
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of epidermal fatty acid-binding protein (E-FABP) and fatty acid synthase (FAS) in human breast cancer and identify the potential markers and therapeutic targets for breast cancer.</p><p><b>METHODS</b>FAS and E-FABP expressions were detected in 76 patients with infiltrating ductal breast carcinoma using RT-PCR, immunohistochemistry and Western blotting. The possible associations of the expression of the two proteins with the major clinicopathological factors were analyzed.</p><p><b>RESULTS</b>E-FABP and FAS expression levels were significantly decreased (P<0.05) in grade III as compared with grades I and II infiltrating ductal breast carcinoma. There was a positive correlation between E-FABP and FAS expressions, but their expressions were not correlated to the clinicopathological factors of the patients except for the tumor grades. High E-FABP expression level in grades I and II tumors were associated with an early increased responsiveness to FAS.</p><p><b>CONCLUSION</b>The variation of the E-FABP and FAS expressions in the lesions is associated with increase of the risk for breast cancer, and the results of this study provide evidence for developing new molecular markers of high-risk lesions and identifying new the targets for breast cancer therapy.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tumeurs du sein
/
Immunohistochimie
/
Marqueurs biologiques tumoraux
/
Technique de Western
/
Carcinome canalaire du sein
/
RT-PCR
/
Protéines de liaison aux acides gras
/
Fatty acid synthases
/
Génétique
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2008
Type:
Article
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