Expression of COX-2 and VEGF-C in squamous cell carcinoma of the tongue and its correlation to lymph node metastasis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 180-183, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-293422
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the coexpression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor-C (VEGF-C) in human squamous cell carcinoma of the tongue (SCCT) and assess their correlations to neoangiogenesis and lymph node metastasis of the tumor.</p><p><b>METHODS</b>Tissue samples of primary SCCT and the metastatic lymph nodes were obtained from 46 patients undergoing surgical resections of SCCT for immunohistochemical detection of COX-2 and VEGF-C expressions.</p><p><b>RESULTS</b>The over-expression rates of COX-2 and VEGF-C was 82.61% and 73.91% in the primary tumor, respectively, significantly higher than those in normal oral mucosa. A significant correlation was found between the expression scores of COX-2 and VEGF-C with a concordance rate of 82.61% (P<0.01) and a kappa value of 0.495 according to Cohen's kappa test (P<0.01). High expression of VEGF-C, but not COX-2, was correlated to the presence of lymph node metastasis (P<0.05). The mean microvessel density was significant higher in tumors with strong positivity for COX-2 or VEGF-C than in tumors with only weak or negative expressions (P<0.001).</p><p><b>CONCLUSION</b>The expressions of COX-2 and VEGF-C are closely correlated in SCCT, and may have clinical value for assessing the prognosis, metastasis and invasion of SCCT, but the mechanism of these proteins in carcinogenesis in SCCT needs further investigation.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tumeurs de la langue
/
Carcinome épidermoïde
/
Facteur de croissance endothéliale vasculaire de type C
/
Cyclooxygenase 2
/
Métastase lymphatique
/
Métabolisme
/
Néovascularisation pathologique
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2008
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS