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Feedforward control strategy and its application in quality improvement of ethanol precipitation process of danhong injection / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1667-1671, 2013.
Article Dans Chinois | WPRIM | ID: wpr-294046
ABSTRACT
In this work, a feedforward control strategy basing on the concept of quality by design was established for the manufacturing process of traditional Chinese medicine to reduce the impact of the quality variation of raw materials on drug. In the research, the ethanol precipitation process of Danhong injection was taken as an application case of the method established. Box-Behnken design of experiments was conducted. Mathematical models relating the attributes of the concentrate, the process parameters and the quality of the supernatants produced were established. Then an optimization model for calculating the best process parameters basing on the attributes of the concentrate was built. The quality of the supernatants produced by ethanol precipitation with optimized and non-optimized process parameters were compared. The results showed that using the feedforward control strategy for process parameters optimization can control the quality of the supernatants effectively. The feedforward control strategy proposed can enhance the batch-to-batch consistency of the supernatants produced by ethanol precipitation.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Précipitation chimique / Normes de référence / Médicaments issus de plantes chinoises / Chimie / Chimie pharmaceutique / Salvia miltiorrhiza / Amélioration de la qualité / Méthodes langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2013 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Précipitation chimique / Normes de référence / Médicaments issus de plantes chinoises / Chimie / Chimie pharmaceutique / Salvia miltiorrhiza / Amélioration de la qualité / Méthodes langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2013 Type: Article