Comparative study on effect of crude and different processed products of epimedium on pharmacokinetics characteristics in mice / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1614-1617, 2013.
Article
de Zh
| WPRIM
| ID: wpr-294057
Bibliothèque responsable:
WPRO
ABSTRACT
To study different impacts of crude epimedium and extracts from different processed epimedium on pharmacokinetic characteristic parameters in mice. To explore the rationality of its processed products, mice were orally administered with crude epimedium and extracting solutions from heated epimedium and processed epimedium. With increased SOD value as an indicator, the relationship between time and equivalent body dose was obtained by using the pharmacological effect method. DAS 2.0 software was adopted to compare their pharmacokinetic parameters. The results showed significant differences in such pharmacokinetic parameters as Cmax and AUC of processed epimedium, heated epimedium and crude epimedium, namely processed epimedium > heated epimedium > crude epimedium. We could come to the conclusion that heated epimedium showed increased bioavailability, while epimedium processed with sheep oil could further promote in vivo absorption.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Médicaments issus de plantes chinoises
/
Pharmacocinétique
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Biodisponibilité
/
Chimie
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Chimie pharmaceutique
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Epimedium
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Relation dose-effet des médicaments
/
Méthodes
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2013
Type:
Article